Try running check disk on all your hard drives.Maybe try disabling select effects within ENB to see if one is at the root cause of it & breaking the others etc.Messed with in-game graphics settings? Like disabling MSAA & Anisotropic Filtering etc to see if any conflict exists there etc.Disable Anti-virus or anything like that also.Basically, do your research & disable everything like that. Nearly everything comes with one now-a-days & a lot are hidden away & you may not know they are running etc. Disable all overlays & such, including MSI Afterburner, Fraps, Nvidia Geforce/Steam/Origin etc overlays.Try different older Graphics Drivers & uninstall your current GPU driver in Windows Safe Mode using DDU (Display Driver Uninstaller).A lot of the new RTX 3000 series Nvidia cards have random weird issues with ENB also. AMD or Nvidia GPU? AMD GPUs have always had a lot of issues with ENB (not sure they are even officially supported, generally they can work, but no support from ENB if you have issues etc).Also, try older versions of ENB (you can find them in this thread)

Tried a default/basic ENB/no presets installed? Latest version? (0.471 was updated 17-02-22 to fix compatibility issues with RagePluginHook).Can you open the ENB menu? ( Shift+Enter by default, also does the ON/OFF toggle work/see a difference? ( Shift+F12 normally).Just try deactivating Windows Update (without it secretly reactivating itself) & you'll see how little control you have even over your own something in here that might help: There's so much crapware in every OS/3rd party app now, it's getting harder & harder to remove/diagnose/fix anything.

Be pretty hard to diagnose unless the issue is repeatable on another machine, which is unlikely.

Step enb not working indoors